Jalan Cerita:
In the future, an outbreak of canine flu leads the mayor of a Japanese city to banish all dogs to an island used as a garbage dump. The outcasts must soon embark on an epic journey when a 12-year-old boy arrives on the island to find his beloved pet.

Pemain:

Bryan Cranston (suara) Chief

Koyu Rankin (suara) Atari Kobayashi

Bob Balaban (suara) King

Edward Norton (suara) Rex

Bill Murray (suara) Boss