Jalan Cerita:
After Megamind, a highly intelligent alien supervillain, defeats his long-time nemesis Metro Man, Megamind creates a new hero to fight, but must act to save the city when his "creation" becomes an even worse villain than he was.

Pemain:

Will Ferrell (suara) Megamind

Tina Fey (suara) Roxanne Ritchi

Jonah Hill (suara) Hal Stewart / Tighten

Brad Pitt (suara) Metro Man

David Cross (suara) Minion