Jalan Cerita:
After Homer accidentally pollutes the town's water supply, Springfield is encased in a gigantic dome by the EPA and the Simpsons are declared fugitives.

Pemain:

Dan Castellaneta (suara) Homer Simpson / Itchy / Barney / Abe Simpson / Stage Manager / Krusty the Clown / Mayor Quimby / Mayor's Aide / Multi-Eyed Squirrel / Panicky Man / Sideshow Mel / Mr. Teeny / EPA Official / Kissing Cop / Bear / Boy on Phone / NSA Worker / Officer / Santa's Little Helper / Squeaky-Voiced Teen

Julie Kavner (suara) Marge Simpson / Selma Bouvier / Patty Bouvier

Nancy Cartwright (suara) Bart Simpson / Maggie Simpson / Ralph / Nelson / Todd Flanders / TV Daughter / Woman on Phone

Yeardley Smith (suara) Lisa Simpson

Hank Azaria (suara) Professor Frink / Comic Book Guy / Moe / Chief Wiggum / Lou / Carl / Cletus / Bumblebee Man / Male EPA Worker / Dome Depot Announcer / Kissing Cop / Carnival Barker / Counter Man / Apu / Drederick Tatum / Sea Captain / EPA Passenger / Robot / Dr. Nick / Wise Guy